El consumo de alcohol, tabaco y drogas se ha convertido en un problema se salud pública a nivel mundial. Los programas de intervención en San Juan del Río, Querétaro tratan de hacer frente a estas dificultades, sin embargo tales programas no están basados en datos de esta población. Se realizó un estudio epidemiológico con una muestra representativa de 992 alumnos de nivel secundaria que contestaron un cuestionario autoaplicable utilizado en diversos estudios a nivel nacional, contiene varias escalas incluyendo las de consumo de sustancias. El objetivo fue determinar la prevalencia del consumo de alcohol, tabaco y otras drogas en esta población, además de comparar y correlacionar tales prevalencias con factores asociados al consumo. La prevalencia de consumo de por lo menos una sustancia es de 63.3%. De estos el 58.3% han consumido alcohol, 22.2% han consumido tabaco, seguido por inhalables con 14.9%, para marihuana es un 13% y dejando a otras drogas con un porcentaje menor a 5%. En cuanto a las relaciones con factores psicológicos se encontró un valor significativo de la impulsividad y el locus asociado a la suerte con casi todas las sustancias, y de factores psicosociales se encontró que la relación con los padres es la más significativa. Palabras clave Prevalencia - Alcohol - Tabaco - Drogas - Relación - Factores psi- cológicos - Factores psicosociales ABSTRACT PREVALENCE OF ALCOHOL, TOBACCO AND DRUGS CONSUMPTION AND ITS RELATIONSHIP WITH PSYCHOLOGICAL AND PSYCHOSOCIAL FACTORS IN ADOLESCENTS OF SAN JUAN DEL RÍO, QRO. MÉXICO The consumption of alcohol, tobacco and drugs has become a public health problem worldwide, however not all places have precise data on consumption, as is the case of the municipality of San Juan del Río, Queretaro, making precise intervention difficult; For this reason an epidemiological study was carried out with a representative sample of 992 secondary school students, who answered a self-applied questionnaire used in several studies at a national level, which contains several scales, including those of substance use. Our objective was to determine the prevalence of alcohol consumption, as well as tobacco and other drug use in this population in addition to comparing and correlating such prevalences with factors associated with consumption. It was found that the prevalence of consumption of at least one substance is 63.3%. A 58.3% have consumed alcohol, 22.2% have used tobacco, followed by inhalants with 14.9%, and marijuana a 13% and leaving other drugs with a percentage lower than 5%. In this research there were also found that psychological factors have significant value of impulsivity and the locus associated with luck was found with almost all substances, and from psychosocial factors it was found that the relationship with parents is the most significant. Key words Prevalence - Alcohol - Tobacco - Drugs - Relationship - Psycho-