Of the different demons that surround and stalk the global population with a force that seems uncontrollable as it unfolds. The COVID-19 pandemic represents, together with other evils of present era, the greatest challenge from State in being able to neutralize its mega-impact from the radiation of normative devices, management and activation of basic resources. Along these lines, this study seeks to analyze the side effects of having deliberated the declaration of a state of exception in the face of a lethal enemy. Well, it is not surprising that the dominant process pandemic has had dissimilar impacts in magnitude and intensity in groups of special vulnerability. From this, it can be recognized that when adopting the necessary measures to guarantee the protection of fundamental rights in scenarios of public calamity, a decentralized and differentiated approach should be considered for treatment of these deprived groups by the State.