El virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus) es el agente infeccioso responsable de la enfermedad COVID-19, decretada pandemia en marzo de 2020 por la OMS. Este virus afecta principalmente el sistema respiratorio, aunque se reconoce a la enfermedad como sistémica, por los efectos inflamatorios, metabólicos e incluso neuropsiquiátricos que produce. Siguiendo esta línea, han sido descritas manifestaciones neurológicas y neurocognitivas tras la infección por el SARSCoV-2. Éstas podrían producirse por invasión directa del nervio olfatorio y su posterior diseminación al sistema nervioso central (SNC). Además, numerosos estudios dan cuenta de la pérdida de sustancia gris en el lóbulo frontal de pacientes graves post Covid, siendo esta región importante para la planificación de los movimientos voluntarios, la regulación de la emoción, la memoria de trabajo, la atención y las funciones ejecutivas. El objetivo de esta investigación es estudiar, las posibles secuelas neurocognitivas, psicoafectivas y clínicas en pacientes que han atravesado la enfermedad, realizando una comparación de grupos entre pacientes internados por cuadros graves y pacientes que han cursado la enfermedad con síntomas leves, derivados del Hospital Interzonal de agudos “Evita”. Palabras clave COVID-19 - Secuelas cognitivas - Síndrome post-covid ABSTRACT PERMANENCE OF NEUROCOGNITIVE, PSYCHOAFFECTIVE AND CLINICAL SYMPTOMS POST COVID-19: A GROUP COMPARISON STUDY The virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus) is the infectious agent responsible for COVID-19, which was declared pandemic by the World Health Organization (WHO) in March 2020. This virus mainly affects the respiratory system, but it is considered as a systemic illness as well, because of the inflammatory, metabolic and neuropsychiatric effects that it produces. There have been described neurological and neurocognitive sequelae after SARS-CoV-2 infection. They can be produced by a direct infection in the olfactory nerve and its posterior dissemination through the nervous central system (NCS), or by the infiltration of immunological cells in the brain. Moreover, many studies show the loss of gray matter in the frontal lobe in critical patients post Covid. It is known the importance of frontal lobe functions in the planification of voluntary movements, regulation of emotion, working memory, attention and executive functions. It has also been demonstrated the association between the hippocampus and declarative memory. The aim of this research is to study the possible neurocognitive, psychoaffective and clinic consequences in patients recovered from Covid who have persistent symptoms. A comparative study will be performed between two groups of patients: severe patients who had been hospitalized and patients with mild symptoms, all of them derived from Hospital Interzonal de agudos “Evita”. Keywords COVID-19 - Cognitive sequels - Post covid syndrome