El objetivo de este trabajo es describir los cambios observados en el malestar psicológico en el escenario pandémico con respecto a la situación pre-pandemia, teniendo en cuenta la brecha por sexo y jefatura de hogar. A su vez, se busca realizar un análisis de la trayectoria del malestar psicológico entre los años 2019 y 2020, estudiando los efectos de los factores personales, contextuales y económicas que podrían incidir sobre la posibilidad de experimentar malestar psicológico. Se observó que el malestar psicológico de las personas se vio sustancialmente resentido en la pandemia. El estrato socio ocupacional, la región urbana, el sexo, y ser jefe del hogar demostraron ser factores que influyen sobre el riesgo de padecer malestar psicológico. Palabras clave Malestar psicológico - Sexo - Jefe de hogar - Pandemia ABSTRACT AFFECTIVE-EMOTIONAL STATES DURING THE PANDEMIC: A LONGITUDINAL ANALYSIS OF INEQUALITIES BY GENDER AND HEAD OF HOUSEHOLD The aim of this study is to describe the changes observed in psychological distress in the pandemic scenario with respect to the pre-pandemic situation, taking into account the gap by sex and head of household. In turn, we seek to perform an analysis of the trajectory of psychological distress between 2019 and 2020, studying the effects of personal, contextual and economic factors that could influence the possibility of experiencing psychological distress. It was observed that people’s psychological distress was substantially resented in the pandemic. Socio-occupational stratum, urban region, sex, and being head of household were shown to be factors influencing the risk of suffering psychological distress. Keywords Psychological distress - Sex - Head of household - Pandemic