Aunque la psicoterapia es efectiva, poco se sabe respecto a sus mecanismos de cambio. Entre los candidatos que se han propuesto, la regulación emocional (RE) ha despertado especial interés por su naturaleza transteórica y transdiagnóstica. Si bien se ha comenzado a estudiar el rol de la RE, aún no se ha explorado en psicoterapia a través de videoconferencia. Para ello, se desagregaron los efectos entre-pacientes (las trayectorias promedio) y efectos intra-pacientes (las trayectorias individuales) de la RE sobre el resultado en 239 pacientes que recibieron psicoterapia cognitivo-comportamental integrativa. La RE se midió con la S-DERS y el resultado con el OQ-30. Se aplicaron modelos multinivel para contemplar la estructura anidada de datos, y poder incluir tanto las trayectorias promedio como individuales. El modelo mostró efectos significativos entre-pacientes, como efectos significativos intra-paciente de la S-DERS sobre el OQ30. Además, se identificaron que los efectos entre-paciente moderan los efectos intra-paciente, indicando que aquellos con menores dificultades iniciales en la RE son los que más se benefician de este tipo de intervenciones. El establecimiento de cómo y qué tipo de paciente se puede beneficiar de intervenciones en la RE a través de videoconferencia resulta relevante para tender a la personalización de la psicoterapia. Palabras clave Psicoterapia integrativa - Mecanismos de cambio - Regulación emocional - Telepsicoterapia ABSTRACT COGNITIVE BEHAVIORAL INTEGRATIVE PSYCHOTHERAPY THROUGH VIDEOCONFERENCE: EMOTION REGULATION AS A MECHANISM OF CHANGE Although psychotherapy is effective, little is known about its mechanisms of change. Among the candidates that have been proposed, emotion regulation (ER) has aroused special interest due to its transtheoretical and transdiagnostic nature. Although the role of ER has begun to be studied, it has not yet been explored in psychotherapy through videoconferencing. To do this, the between-patient effects (the average trajectories) and withinpatient effects (the individual trajectories) of ER were disaggregated on the outcome in 239 patients who received integrative cognitive-behavioral psychotherapy. ER was measured with the S-DERS and the outcome with the OQ-30. Multilevel models were applied to account for the nested structure of the data, and to be able to include both the average and individual trajectories. The model showed significant between-patient effects, such as significant within-patient effects of S-DERS on OQ-30. In addition, it was identified that between-patient effects moderate within-patient effects, indicating that those with the least initial difficulties in ER are the ones who benefit the most from this type of interventions. The establishment of how and what type of patient can benefit from interventions in ER through videoconference is relevant to tend towards the personalization of psychotherapy. Keywords Integrative psychotherapy - Mechanisms of change - Emotion