El objetivo del presente trabajo, fue explorar el impacto psicológico en las pautas de autocuidado de los/as trabajadores/as de la salud del sistema sanitario argentino, que se encontraban trabajando durante la pandemia por COVID-19, iniciándose el aislamiento social preventivo y obligatorio el 20 de marzo de 2020. Se trata de un estudio descriptivo, con diseño no experimental de corte transversal. La muestra estuvo constituida por 309 adultos argentinos/as entre 22 y 75 años (MEDAD = 42.82, DE = 12.54, 19.7% varones y 80.3% mujeres). Los resultados informaron que la incertidumbre presentó una alta implicancia negativa sobre el comportamiento. Se observó una disposición mayoritaria de los/as participantes a tener comportamientos y prácticas tendientes al autocuidado, tales como el bienestar físico, emocional, mental y social. Palabras clave Impacto psicológico - Pautas de autocuidado - Incertidumbre - pandemia por COVID-19 ABSTRACT PRELIMINARY STUDY ABOUT SELF-CARE PATTERNS IN HEALTH CARE STAFF IN COVID-19 CONTEXT The aim of the present investigation was to explore the potential psychological impact on self-care patterns in health care staff while they were working on Argentinian Health Care System during the preventive and compulsory social isolation related to Covid-19´s Pandemic from March 20 of 2020 to the present day. In this descriptive study, with a non-experimental cross-sectional design, the sample was made up of 309 Argentine adults between 22 and 75 years old (MAGE= 42.82, SD = 12.54, 19.7% male and 80.3% female). Results have reported so far, a high implication on behavior related to uncertainty.Willingness towards behaviors and practices tending to self-care including physical, emotional and social well-being was observed of the participants. Keywords Psychological impact - Self-care patterns - Uncertainty - COVID-